CRF grant ‘Identification and characterization of the lysosomal transporter involved in cysteamine-mediated cysteine efflux’
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چکیده
We previously identified several members of the SLC7 transporter family as potential system c transporters based on immunofluorescence data and, for functionally characterized members, on cysteamine-cysteine competition experiments. CAT2A, CAT2B, an orphan CAT-like protein named SLC7A14 and, to a lesser extent, CAT1 appeared as good system c candidates. However, it is still unknown which of these transporters is (or are) actually involved in cysteaminemediated cystine lysosomal depletion.
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CRF grant “Molecular study of lysosomal transporters involved in the cystine- depleting effect of cysteamine”
The long-term objective of this grant is to identify the membrane transporters underlying the cystine-depleting effect of cysteamine as this would provide a rationale to improve its efficiency or discover more efficient, better tolerated drugs. According to the current model of cysteamine therapy, cystine depletion is mediated by an unknown cationic amino acid transporter, which exports a mixed...
متن کاملCRF grant “Molecular study of lysosomal transporters involved in the cystine‐depleting effect of cysteamine”
transporters involved in the cystine‐depleting effect of cysteamine” Progress Report‐ January 2013 Principal investigators: Bruno Gasnier, Ph.D. (Paris) Ellen Closs, Ph.D. (Mainz) The long‐term objective of this grant is to identify the membrane transporters underlying the cystine‐ depleting effect of cysteamine as this would provide a rationale to improve its efficiency or discover more eff...
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متن کاملCelecoxib Up Regulates the Expression of Drug Efflux Transporter ABCG2 in Breast Cancer Cell Lines
Elevated expression of the drug efflux transporter ABCG2 seems to correlate with multidrug resistance of cancer cells. Specific COX-2 inhibitor celecoxib has been shown to enhance the sensitivity of cancer cells to anticancer drugs. To clarify whether ABCG2 inhibition is involved in the sensitizing effect of celecoxib, we investigated whether the expression of ABCG2 in breast cancer cell lines ...
متن کاملDetection and characterization of carrier-mediated cationic amino acid transport in lysosomes of normal and cystinotic human fibroblasts. Role in therapeutic cystine removal?
The discovery of a trans-stimulation property associated with lysine exodus from lysosomes of human fibroblasts has enabled us to characterize a system mediating the transport of cationic amino acids across the lysosomal membrane of human fibroblasts. The cationic amino acids arginine, lysine, ornithine, diaminobutyrate, histidine, 2-aminoethylcysteine, and the mixed disulfide of cysteine and c...
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